O-186 The implementation of a novel algorithm for monitoring ovulation in an IVF mixed protocol may simplify stimulation monitoring

Abstract Study question Which patients are eligible to skip ovulation monitoring before day 10 in In Vitro Fertilization (IVF) and what the financial implications? Summary answer Thanks our innovative gonadotropin prescription algorithm, with low ovarian reserve maximum stimulation may not require until of IVF. What is known already most fertility clinics, standard procedure for IVF early on 6 stimulation. Our focus personalizing protocol by identifying optimal dose gonadotropin. With aid unique we aim streamline monitoring. Frequent ultrasound examinations required can impose restrictions create a burden patients, resulting increased costs both physicians. design, size, duration retrospective study conducted from April 2021 August 2022 at OVO clinic Montreal (Canada), participants included all over 18 years old who underwent an cycle utilizing antagonist customized mixed consisting follitrophin delta human menopausal gonadotropin, based patient's weight anti-Mullerian hormone level. The sudy was approved Veritas IRB, independent ethic committee. Tracking number :2023-3189-13659-2 Participants/materials, setting, methods study, dosages were assigned either algorithm (group 1) or physician's discretion 2). Ultrasound hormonal analysis performed 6. Following evaluation, adjustments dosage made if necessary. common trigger criteria presence least three follicles measuring between 16 22mm. Main results role chance 714 meeting inclusion criteria. group 1, there high percentage stimulated doses (80.3% compared 22.5% No modifications incidents hyperstimulation syndrome observed 1. Only 4.5% (n = 16) triggered (on 9). non-maximal population, treated according A) experienced significantly fewer changes only B) (24.6% vs 46.9%, p < 0.001). gonadotropins notably more frequent adjusted B (46.9% 24.6%, A higher risk population maximal (64.6% 27.5%, 0.01). These findings suggest that be necessary dose. This could result 478 blood tests being avoided context this study. Limitations, reasons caution data obtained through analysis. However, pose delaying cancellation cycle, unnecessary treatment continuation. Wider implications significant indicates that, thanks would adequate Further validation strategy randomized prospective use different gonadotropins. Trial registration non applicable